In an increasingly interconnected and digital world, the role of Chief Information Security Officers (CISOs) has become crucial in safeguarding organizations against evolving cyber threats. However, CISOs face numerous challenges in effectively handling and mitigating these threats, ranging from resource constraints to the ever-changing threat landscape. This article delves into the challenges faced by CISOs in their efforts to protect organizations from cyber threats. By exploring the key obstacles, strategies for overcoming them, and best practices, this article aims to provide valuable insights for CISOs and organizations seeking to enhance their threat management capabilities.